New Horizons in Cancer Theranostics
Discovery and
Naming Exosomes
Cancer Diagnosis:
Exosomes carry cancer-specific biomarkers, including proteins, lipids, and nucleic acids, which can be utilized for non-invasive cancer diagnosis. For instance, certain proteins like CD24, EDIL3, and fibronectin have been identified on plasma exosomes in early-stage breast cancer, while lowered levels of HSP90, VTN, and MAPK1 have been observed in colorectal cancer patient serum exosomes. By selectively capturing and quantifying these tumor-associated exosomes using its integrated method, QUICK has the potential to diagnose multiple types of cancer in a non-invasive manner.
Cancer Diagnosis:
Exosomes carry cancer-specific biomarkers, including proteins, lipids, and nucleic acids, which can be utilized for non-invasive cancer diagnosis. For instance, certain proteins like CD24, EDIL3, and fibronectin have been identified on plasma exosomes in early-stage breast cancer, while lowered levels of HSP90, VTN, and MAPK1 have been observed in colorectal cancer patient serum exosomes. By selectively capturing and quantifying these tumor-associated exosomes using its integrated method, QUICK has the potential to diagnose multiple types of cancer in a non-invasive manner.
Cancer Therapeutics:
Exosomes offer great potential in cancer therapeutics by delivering functional molecules with high target specificity. For example, MSC-derived exosomes carrying TRAIL have shown the ability to induce apoptosis in cancer cells. QUICK's selective capturing feature can aid in extracting this specific subgroup of exosomes. Additionally, exosomes can be engineered by adding therapeutic proteins or modifying their surface. QUICK serves as a quality control tool and can aid in the discovery of novel therapeutic molecules. Overall, exosomes and QUICK have the potential to revolutionize cancer treatment.
Cancer Therapeutics:
Exosomes offer great potential in cancer therapeutics by delivering functional molecules with high target specificity. For example, MSC-derived exosomes carrying TRAIL have shown the ability to induce apoptosis in cancer cells. QUICK's selective capturing feature can aid in extracting this specific subgroup of exosomes. Additionally, exosomes can be engineered by adding therapeutic proteins or modifying their surface. QUICK serves as a quality control tool and can aid in the discovery of novel therapeutic molecules. Overall, exosomes and QUICK have the potential to revolutionize cancer treatment.
Cancer Treatment Monitoring:
Exosomes offer great potential in cancer therapeutics by delivering functional molecules with high target specificity. For example, MSC-derived exosomes carrying TRAIL have shown the ability to induce apoptosis in cancer cells. QUICK's selective capturing feature can aid in extracting this specific subgroup of exosomes. Additionally, exosomes can be engineered by adding therapeutic proteins or modifying their surface. QUICK serves as a quality control tool and can aid in the discovery of novel therapeutic molecules. Overall, exosomes and QUICK have the potential to revolutionize cancer treatment.
Cancer Treatment Monitoring:
Exosomes offer great potential in cancer therapeutics by delivering functional molecules with high target specificity. For example, MSC-derived exosomes carrying TRAIL have shown the ability to induce apoptosis in cancer cells. QUICK's selective capturing feature can aid in extracting this specific subgroup of exosomes. Additionally, exosomes can be engineered by adding therapeutic proteins or modifying their surface. QUICK serves as a quality control tool and can aid in the discovery of novel therapeutic molecules. Overall, exosomes and QUICK have the potential to revolutionize cancer treatment.
Beyond Cancer: Novel Insights into Exosomes
Exosome Heterogeneity Assessment:
Exosomes are a highly heterogeneous population of vesicles. This heterogeneityis introduced by a variety of factors including the cellular origin, molecular composition, size, number, and functionality. Due to the overlap of these parameters with each other, it is very challenging to classify exosomes into subgroups and identify their roles. Discovering the heterogeneity of exosomes can therefore provide a deeper understanding of physiological and pathophysiological processes. To this end, QUICK can address the heterogeneity of exosomes by selectively quantifying its subgroups through targeting particular surface proteins on their surface.
Exosome Heterogeneity Assessment:
Exosomes are a highly heterogeneous population of vesicles. This heterogeneityis introduced by a variety of factors including the cellular origin, molecular composition, size, number, and functionality. Due to the overlap of these parameters with each other, it is very challenging to classify exosomes into subgroups and identify their roles. Discovering the heterogeneity of exosomes can therefore provide a deeper understanding of physiological and pathophysiological processes. To this end, QUICK can address the heterogeneity of exosomes by selectively quantifying its subgroups through targeting particular surface proteins on their surface.
Differentiation of Exosomes of Different Cell Types:
Even though exosomes commonly contain some certain functional molecules (i.e. CD9, CD63,CD81), the main difference of exosomes from different sources is considered to be their particular mode of biogenesis as it decides on the cargo contents and functions. Since the detection and tracking of such molecules can help understand the mechanism of unresolved metabolic functions, it is still one of the aspects of exosome research. QUICK, with its superior approach in specific targeting, can step in to overtake the duty.
Differentiation of Exosomes of Different Cell Types:
Even though exosomes commonly contain some certain functional molecules (i.e. CD9, CD63,CD81), the main difference of exosomes from different sources is considered to be their particular mode of biogenesis as it decides on the cargo contents and functions. Since the detection and tracking of such molecules can help understand the mechanism of unresolved metabolic functions, it is still one of the aspects of exosome research. QUICK, with its superior approach in specific targeting, can step in to overtake the duty.
Assessment of Exosome Storage Conditions
For clinical use, exosomes should be stored in conditions that preserve their structural integrity, and more importantly, their molecular composition. Towards standardization of the storage conditions of exosomes, one recent study investigated the comparative effects of phosphate buffered saline (PBS) vs. 5% sucrose as storage media. The findings demonstrated that in addition to the resultant discrepancies in size, concentration, and morphology, different storage conditions also lead to differences in the expression of common surface proteins CD63 and CD81. While this suggests the molecular composition of exosomes should also be taken into consideration while assessing the ideal storage for exosomes, the selective capturing of QUICK which can target common surface proteins can be a useful tool in such assessment.
Assessment of Exosome Storage Conditions
For clinical use, exosomes should be stored in conditions that preserve their structural integrity, and more importantly, their molecular composition. Towards standardization of the storage conditions of exosomes, one recent study investigated the comparative effects of phosphate buffered saline (PBS) vs. 5% sucrose as storage media. The findings demonstrated that in addition to the resultant discrepancies in size, concentration, and morphology, different storage conditions also lead to differences in the expression of common surface proteins CD63 and CD81. While this suggests the molecular composition of exosomes should also be taken into consideration while assessing the ideal storage for exosomes, the selective capturing of QUICK which can target common surface proteins can be a useful tool in such assessment.
Niche Questions on Exosomes
The key for science is curiosity. So, you may just as well be curious about some unanswered questions regarding exosomes other than the widespread ones. For instance, a recent study focused on the circadian regulation of the protein cargo content of different types of extracellular vesicles, including exosomes. Even in this kind of out-of- the-box ideas on your research, QUICK can help you track the variation orfluctuation in the molecular content of exosomes.
Niche Questions on Exosomes
The key for science is curiosity. So, you may just as well be curious about some unanswered questions regarding exosomes other than the widespread ones. For instance, a recent study focused on the circadian regulation of the protein cargo content of different types of extracellular vesicles, including exosomes. Even in this kind of out-of- the-box ideas on your research, QUICK can help you track the variation orfluctuation in the molecular content of exosomes.
